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Orit Bar-Am Selected Research

rasagiline (Azilect)

9/2015Effect of long-term treatment with rasagiline on cognitive deficits and related molecular cascades in aged mice.
8/2012Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice.
1/2012I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline.
1/2012From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease.
7/2011TVP1022 attenuates cardiac remodeling and kidney dysfunction in experimental volume overload-induced congestive heart failure.
6/2011The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion.
3/2011Iron-chelating backbone coupled with monoamine oxidase inhibitory moiety as novel pluripotential therapeutic agents for Alzheimer's disease: a tribute to Moussa Youdim.
11/2010Rasagiline: a novel anti-Parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity.
3/2010The neuroprotective mechanism of 1-(R)-aminoindan, the major metabolite of the anti-parkinsonian drug rasagiline.
1/2010Propargylamine containing compounds as modulators of proteolytic cleavage of amyloid-beta protein precursor: involvement of MAPK and PKC activation.
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Orit Bar-Am Research Topics

Disease

21Alzheimer Disease (Alzheimer's Disease)
09/2017 - 10/2002
17Neurodegenerative Diseases (Neurodegenerative Disease)
09/2017 - 02/2005
11Neuroblastoma
04/2010 - 10/2002
9Parkinson Disease (Parkinson's Disease)
03/2015 - 12/2003
5Lewy Body Disease (Lewy Body Dementia)
01/2010 - 10/2006
4Dementia (Dementias)
04/2012 - 12/2006
4Pheochromocytoma
01/2012 - 09/2004
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
01/2017 - 03/2011
2Inflammation (Inflammations)
12/2014 - 08/2007
2Hypoxia (Hypoxemia)
02/2014 - 08/2012
2Basal Ganglia Diseases (Basal Ganglia Disease)
04/2012 - 01/2011
2Diabetes Mellitus
06/2010 - 11/2009
2Parkinsonian Disorders (Parkinsonism)
04/2010 - 11/2007
1Atrophy
01/2017
1Neuroinflammatory Diseases
01/2016
1Mitochondrial Diseases (Mitochondrial Disease)
01/2016
1Cognitive Dysfunction
12/2015
1Brain Hypoxia (Cerebral Hypoxia)
12/2014
1Type 2 Diabetes Mellitus (MODY)
12/2014
1Hepatocellular Carcinoma (Hepatoma)
01/2013
1Memory Disorders (Memory Loss)
09/2012
1Amyloid Plaque
05/2012
1Gliosis
04/2012
1Heart Failure
07/2011
1Fibrosis (Cirrhosis)
07/2011
1Hypertrophy
07/2011
1Infarction (Infarctions)
06/2011
1Wounds and Injuries (Trauma)
06/2011
1Myocardial Infarction
06/2011
1Cardiotoxicity
09/2008
1Starvation
09/2008
1Neoplasms (Cancer)
09/2008

Drug/Important Bio-Agent (IBA)

22rasagiline (Azilect)FDA Link
09/2015 - 10/2002
20IronIBA
09/2017 - 02/2005
17Pharmaceutical PreparationsIBA
09/2017 - 06/2004
16Monoamine Oxidase (MAO)IBA
01/2016 - 12/2003
13(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamateIBA
04/2012 - 10/2002
12Neuroprotective AgentsIBA
01/2016 - 09/2004
9Amyloid (Amyloid Fibrils)IBA
01/2016 - 10/2002
9Chelating AgentsIBA
03/2015 - 02/2005
9Proteins (Proteins, Gene)FDA Link
12/2014 - 10/2002
8Cholinesterases (Cholinesterase)IBA
01/2016 - 10/2002
7propargylamineIBA
09/2017 - 08/2005
6Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)IBA
01/2017 - 10/2005
6N-propargylIBA
08/2012 - 05/2003
4AntioxidantsIBA
08/2012 - 10/2005
4methyl carbamateIBA
04/2012 - 10/2002
4Reactive Oxygen Species (Oxygen Radicals)IBA
07/2011 - 09/2008
3Therapeutic UsesIBA
01/2017 - 06/2010
3Oxidopamine (6 Hydroxydopamine)IBA
03/2015 - 11/2007
3Insulin (Novolin)FDA Link
02/2014 - 11/2009
3Cholinesterase Inhibitors (Anticholinesterases)IBA
01/2011 - 06/2004
3(N-propargyl-(3R) and (3S) aminoindan-5-yl)-ethyl methyl carbamateIBA
06/2004 - 10/2002
2EnzymesIBA
01/2016 - 02/2009
2MetalsIBA
01/2016 - 08/2007
2Oxyquinoline (8 Hydroxyquinoline)FDA Link
08/2012 - 01/2010
2NeurotoxinsIBA
04/2010 - 11/2007
2Peroxynitrous Acid (Peroxynitrite)IBA
04/2010 - 11/2007
2Rivastigmine (Exelon)FDA LinkGeneric
01/2010 - 10/2006
2Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric
02/2009 - 09/2008
2CatalaseIBA
02/2009 - 09/2008
2Messenger RNA (mRNA)IBA
02/2009 - 08/2005
2Caspase 3 (Caspase-3)IBA
09/2008 - 01/2007
15- (2- (methylprop- 2- ynylamino)ethyl)quinolin- 8- olIBA
01/2017
1Glutamic Acid (Glutamate)FDA Link
01/2016
1Peptides (Polypeptides)IBA
01/2016
1Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA
03/2015
1Dopamine (Intropin)FDA LinkGeneric
03/2015
11- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
03/2015
1Glucose (Dextrose)FDA LinkGeneric
02/2014
1Fructose-Bisphosphate Aldolase (Aldolase)IBA
02/2014
1Insulin ReceptorIBA
02/2014
1Ferritins (Ferritin)IBA
01/2013
1Presenilin-1IBA
09/2012
1Streptozocin (Streptozotocin)FDA Link
04/2012
1Acetylcholine (Acetylcholine Chloride)FDA Link
04/2012
1Mitogen-Activated Protein Kinase 3IBA
01/2012
1AcetylcholinesteraseIBA
01/2012
1Brain Natriuretic Peptide (Natrecor)FDA Link
07/2011
1lactacystinIBA
03/2011
1Levodopa (L Dopa)FDA LinkGeneric
11/2010
1Selegiline (E250)FDA LinkGeneric
01/2010
1CarbamatesIBA
01/2010
1Free RadicalsIBA
11/2009
1NAD (NADH)IBA
02/2009
1PeroxiredoxinsIBA
02/2009
1Glutathione Reductase (Glutathione-Disulfide Reductase)IBA
02/2009
1quinone (benzoquinone)IBA
02/2009
1Oxidoreductases (Dehydrogenase)IBA
02/2009
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2008
1Cardiotonic Agents (Cardiac Stimulants)IBA
09/2008
1AnthracyclinesIBA
09/2008
1Antidepressive Agents (Antidepressants)IBA
05/2008
1activin AIBA
11/2007
1inhibin beta A subunitIBA
11/2007
1FlavonoidsIBA
08/2007
1TeaIBA
08/2007
1epigallocatechin gallate (epigallocatechin-3-gallate)IBA
08/2007

Therapy/Procedure

4Therapeutics
07/2011 - 08/2007
1Denervation
01/2017